CIRCULATORY HEALTH · VASCULAR SUPPORT · HEALTHY AGING
Support Healthy Circulation Every Day
Made in Japan with clinically researched NSK-SD® nattokinase and Elastin F. Choose between our Everyday Maintenance (2,000 FU) or Ultimate Strength (4,000 FU) formulas to fit your lifestyle.
- NSK-SD® Nattokinase
- Elastin F
- Delayed-release capsule
- Available in 2,000 & 4,000 FU
WATSONS HWB AWARDS 2020—2025
Best Selling
Cardiovascular Supplement
UNITY AWARDS 2018—2025
Best Brand
Cardiovascular Supplement
TRUSTED WORLDWIDE
55,000+ boxes sold
Across the VesseCLEAR range
WHY IT MATTERS
Why Circulation Matters As You Age
Healthy blood vessels are clear and flexible, letting blood move smoothly throughout the body.
With age and everyday habits, vessels can gradually lose some of that suppleness, and circulation can slow. Supporting vascular flexibility and steady blood flow is part of staying active and feeling your best as the years go by.
AT A GLANCE
Why VesseCLEAR Is Different
- Branded ingredient
- Includes flexibility support
- Delayed-release capsule
- Made in Japan
- Non-GMO & Vitamin K2-free
- Available in two strengths
Compare Our Formula
Every formula is built on premium ingredients for everyday support. Choose by your goal.
← Swipe horizontally to view full matrix →
VesseCLEAR EXDAILY CARE |
Ultimate VesseCLEAR EXHIGH STRENGTH · MOST POPULAR |
VesseCLEAR CXHOLISTIC WELLNESS |
|
|---|---|---|---|
| Active Ingredient | 2,000 FU | 4,000 FU | 2,000 FU |
| Key Partner Ingredient | Elastin F (75 mg) | Elastin F (75 mg) | Gamma Oryzanol / ORYZA GAMMAX® + BioPerine® |
| Best For | Everyday wellness | Advanced support | Holistic health |
| Circulation Support | ✓ | ✓✓ | ✓ |
| Vascular Flexibility | ✓ | ✓ | - |
| Cholesterol Support / Vegan Friendly | - | - | ✓ |
| Capsule type | DRcaps® Acid-resistant | DRcaps® Acid-resistant | DRcaps® Acid-resistant |
| Vitamin K2-free | ✓ | ✓ | ✓ |
| Price | $28.50 | $34.50 | $29.90 |
| Learn More | Learn More | Learn More |
Hear From Our Satisfied Customers
See what our satisfied customers are saying.
Proven Benefits
Why People Choose VesseCLEAR
A premium formulation backing your active lifestyle with premium science.
Supports Healthy Blood Flow
Helps your body keep blood moving smoothly, day to day.
Supports Vascular Wellness
Marine Elastin F helps keep blood vessels supple and elastic.
Supports Healthy Aging
A simple, effective daily habit for staying active and energized as you age.
Target Audience
Is This Product Right For You?
It may be an excellent fit for adults who:
- Notice cold, numb, or tingling hands or feet
- Sit for long stretches or have a sedentary, low-activity routine
- Have circulatory, blood pressure, or heart concerns in the family history
- Want to preserve robust vascular flexibility as part of healthy aging
- Prefer one convenient, easy-to-swallow daily vegecap
What's Inside VesseCLEAR EX
Two powerful ingredients working together for your wellness.
NSK-SD® Nattokinase
Supports healthy blood flow
A proprietary enzyme studied for supporting your body's natural processes.
Elastin F
Supports vascular flexibility
A readily absorbable peptide that supports the suppleness of blood-vessel walls.
A Dual-Action Approach
Studied for supporting the body's own natural processes through two complementary actions.
Nattokinase NSK-SD® help dissolve the web-like fibrin formed in the blood vessels.
Action 1 · Direct
Supports natural processes
Studied for its role in supporting the body's natural processes.
Action 2 · Supportive
Works with your own system
Also studied for helping the body's own balancing enzymes work more freely.
This is a dietary supplement for general wellness, not a medicine.
Not All Nattokinase Is The Same
Nattokinase products aren't identical — they're made from different strains of the bacterium Bacillus subtilis natto. NSK-SD® is produced from one specific, genetically-verified strain. Here's how it compares.
RECOGNISED IN JAPAN
Leader & Pioneer in Nattokinase
At the forefront of nattokinase research and innovation, advancing heart health and circulatory wellness through science-backed excellence.
DEVELOPED BY
Japan Bio Science Laboratory
Pioneering research and development in nattokinase science with advanced technology and rigorous quality standards.
RECOGNISED BY
Japan Health & Nutrition Food Association
&
Japan Nattokinase Association
Clinical Insights & Expert Education
How I Use Nattokinase safely
Dr. Ford Brewer, MD, MPH, explains the medical science of arterial plaque, proper enzyme safety profiles, and clinical evidence on how nattokinase supports clear arteries.
Can Nattokinase Support Plaque Regression?
An in-depth biochemical review on how fermented soybean enzymes work at the molecular level, detailing randomized controlled trials and clinical dosing strategies.
Expand to see why NSK-SD® is different
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| NSK-SD® nattokinase | Other nattokinase sources |
|---|---|
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✓
Genetically characterized
Verified, documented DNA sequence.
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?
Different genetic profiles
Strain identity often undisclosed or unverified.
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✓
Standardized fermentation
Proprietary process for consistent production.
|
?
Variable manufacturing
Fermentation methods may differ between manufacturers.
|
|
✓
Consistency
Rigorous quality control for purity, potency and safety.
|
?
Inconsistent quality
Potency, purity and activity can vary across batches.
|
|
✓
55+ scientific studies
Globally validated for safety and efficacy across laboratory, animal and human trials.
|
?
Limited public research
Fewer published studies and clinical data.
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Same FU on the label ≠ the same ingredient
▼Same FU on the label ≠ the same ingredient
Ingredient identity and purification matter as much as the number on the bottle.
Recognized and researched in Japan
▼Recognized and researched in Japan
NSK-SD® is developed by Japan Bio Science Laboratory, the pioneer of nattokinase, through a patented, premium-grade process. All VesseCLEAR products are recognized by the Japan Health & Nutrition Food Association and the Japan Nattokinase Association for its quality and authenticity.
Meet Elastin F — The 'Elastic Protein'
Collagen gets structural attention, but cardiovascular elasticity comes from elastin — a protein roughly 1000× more flexible than collagen. It's what keeps blood vessels supple. Your body makes less of it with age, while UV and sugar speed the loss. VesseCLEAR EX tops up your day with premium Elastin F.
1000×
More flexible than collagen — elasticity is elastin's job
~50%
Of the aorta is elastin — keeping your major vessels resilient
80%
Low-molecular-weight peptides (<1000) for ready absorption
Smoother, springier skin
Clinically studied to support dermal elasticity, soften the appearance of fine wrinkles, and refine skin grain texture.
Supple blood vessels
Studied to promote natural flexibility and structural resilience of vessel walls, including the elastin-rich aorta.
Sparks youth proteins
Signals skin fibroblast synthesis to support your body's organic production of fresh structural elastin and collagen fibers.
Bonus everyday comfort
Supports full body mobility by maintaining resilient flexibility inside joint structures for active aging comfort.
BSE-free
MARINE SOURCE
Why bonito fish — not beef?
Traditional elastin comes from bovine (beef) ligament, which carries mad-cow (BSE) concerns. Elastin F is a premium Japanese peptide from marine bonito fish instead — heat- and acid-stable, highly soluble, and enzyme-processed so it stays intact through manufacturing and digestion.
Acid-Resistant Capsule Technology
VesseCLEAR EX uses DRcaps® delayed-release capsules that protect the active ingredients from stomach acid and release them where they're absorbed best.
DRcaps® acid-resistant
Ordinary capsules
✓
Resistant to stomach acid — ingredients aren't destroyed on the way down.
✗
Dissolve in the stomach — exposed to acid early.
✓
Targeted release in the small intestine, where absorption happens.
✗
Release in the stomach, which may cause irritation.
✓
Protects the stomach lining and shields the active ingredients.
✗
Ingredients may degrade before they're absorbed.
✓
Stable and longer-lasting against everyday body conditions.
✗
Less stable and may degrade faster.
Complete Cardiovascular Support
Add VesseCLEAR CX
Pair your chosen VesseCLEAR EX formula (2,000 FU or 4,000 FU) with VesseCLEAR CX for complete, multi-action cardiovascular coverage — supporting clear, flexible vessels alongside blood pressure, cholesterol, triglyceride and blood glucose levels.
Usage & Dosage Guidelines
Follow these guidelines for both everyday maintenance and serious circulatory support.
Supplement Facts
Amount Per Serving
Nattokinase NSK-SD®
100 mg*
providing 2,000 fibrin units (FU) of activity
Elastin F
75 mg*
extracted from bonito fish
Other Ingredients: HydroXYpropyl Methylcellulose (HPMC), Maltodextrin, Amorphous Silicon Dioxide, Magnesium Stearate.
CONTAINS: SOY
NO Gluten, Yeast, Milk Derivatives, Preservatives, Wheat, Artificial Coloring or Flavoring.
VesseCLEAR EX
Contents: 30 vegecaps
For general health maintenance:
1 capsule daily or as directed by a healthcare practitioner.
Take after dinner or before bedtime.
For serious health concerns:
2 to 3 capsules daily at regular intervals.
1 capsule – 2 times daily every 12 hours OR 1 capsule, 3 times daily every 8 hours.
Ultimate VesseCLEAR EX
Contents: 30 vegecaps
For intensive circulation and immune support:
1 capsule daily or as directed by a healthcare practitioner.
Take after dinner or before bedtime.
For comprehensive full-body wellness:
Pair with 1 serving of VesseCLEAR CX daily.
Supplement Facts
Amount Per Serving
Nattokinase NSK-SD®
100 mg*
providing 4,000 fibrin units (FU) of activity
Elastin F
75 mg*
Elastin peptides extracted from bonito fish
Other Ingredients: HydroXYpropyl Methylcellulose (HPMC), Maltodextrin, Amorphous Silicon Dioxide, Magnesium Stearate.
CONTAINS: SOY, FISH (BONITO)
NO Gluten, Yeast, Milk Derivatives, Preservatives, Wheat, Artificial Coloring or Flavoring.
Caution: Nattokinase NSK-SD® is derived from soybean and some traces of soy may present in the final product. Please exercise caution if you are allergic to soybean. Individuals on blood thinning therapy should seek medical advice before taking. It is strongly recommended to stop taking nattokinase at least 2 weeks before and after a scheduled surgery. Dietary supplements are not a substitute for a healthy diet. If you are pregnant, nursing or taking any medication, please consult your physician before consuming any supplements. This product is not intended to diagnose, treat, cure or prevent any disease.
Frequently Asked Questions
What is Nattokinase NSK-SD®?
NSK-SD® is the brand name of a proprietary Nattokinase — an enzyme extracted from traditional Japanese natto — developed by Japan Bio Science Laboratory. It’s studied for supporting the body’s natural processes that help maintain healthy blood flow, and is made with a patented purification process for high purity and stability.
What is the recommended daily dosage?
One capsule daily, providing 2,000 FU of nattokinase NSK-SD® and 75 mg of Elastin F. For greater needs, Ultimate VesseCLEAR EX offers a double-strength 4,000 FU dose. Do not exceed the recommended dose.
Is VesseCLEAR EX safe?
VesseCLEAR EX uses non-GMO nattokinase and fish-derived elastin, both supported by extensive research and a long track record. As with any supplement, it isn’t suitable for everyone — please see the safety note shown near the buy buttons, and consult your doctor if any of those situations apply to you.
Can I take VesseCLEAR EX with other medication?
If you take anticoagulant or antiplatelet medication, are pregnant or nursing, or are scheduled for surgery, speak to your doctor before taking any nattokinase supplement, and do not change prescribed medication without medical advice.
How long until I notice anything?
As a dietary supplement, VesseCLEAR EX is intended for consistent daily use as part of a healthy lifestyle. It is not a medicine, and experiences vary from person to person.
Will the enzyme survive stomach acid?
NSK-SD® is unusually robust: in testing it retained roughly 75–80% of its activity after exposure to stomach-strength acid, and it stays stable for up to 42 months at room temperature — no refrigeration needed.